At what time will the use of the Sinus Rinse be most beneficial? In the morning or before bedtime? Author: Roger Buffett Sinus rinse can be used at any time of the day. However, if the procedure is done at night, we recommend that you rinse at least one to two hours before going to bed or leaving your home in order to avoid the occasional, accidental drainage of the so Last modified:07-01-2009, 6:19 am Number of views:1202 Ketan C. Mehta, MD Diplomate, certified by American Boards of Internal Medicine, Pulmonary Medicine and Critical Care Medicine. Disclaimer