Effect of Ringer-Lactate and isotonic saline solutions on mucociliary clearance of tracheal epithelium: an experimental study in rats.

Unal M, Seymen HO.

Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Mersin University, Turkey. muunal@hotmail.com

Isotonic saline solution is frequently used in nasal and tracheal lavage. In a previous clinical study, it was found that Ringer-Lactate solution, as a nasal lavage, was better for mucociliary clearance function than isotonic saline solution after nasal septal surgery. In this experimental study, the effects of Ringer-Lactate and isotonic saline solutions on mucociliary clearance of healthy rat tracheal epithelium were investigated by measuring the transport of carbon particles. We found that tracheal segments that were irrigated with Ringer-Lactate had better mucociliary transport than those irrigated with isotonic saline (p = 0.035).

PMID: 12238674 [PubMed - indexed for MEDLINE]

 
Ringer-Lactate solution versus isotonic saline solution on mucociliary function after nasal septal surgery.

Unal M, Gorur K, Ozcan C.

Department of Otorhinolaryngology-- Head and Neck Surgery, Mersin University, Faculty of Medicine, Mersin, Turkey. muunal@hotmail.com

Irrigation with isotonic saline is one of the most frequently used solutions after nasal surgery. However, the effect of saline solutions on mucociliary clearance is not well known. In a previous study, it was found that isotonic saline solution had a negative effect on ciliary beat frequency but Ringer-Locke solution had no effect in vitro. In this study we compared the effects of Ringer-Lactate solution and isotonic saline solution on mucociliary transport time before, and after, nasal septal surgery in patients with nasal septal deviation. We found that patients who used Ringer-Lactate solution as irrigation after surgery had a significantly better mucociliary transport time than the patients using isotonic saline solution (p < 0.05). In conclusion, it is better to use Ringer-Lactate solution instead of 0.9 per cent saline solution for nasal irrigation.

Publication Types:

• Clinical Trial
• Randomized Controlled Trial